Title of article
Synthesis of the glucuronide metabolite of ABT-751
Author/Authors
Engstrom، نويسنده , , Kenneth M. and Henry، نويسنده , , Rodger F. and Marsden، نويسنده , , Ian، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
1359
To page
1362
Abstract
A linear synthesis of the glucuronide metabolite of ABT-751 was replaced with a convergent synthesis that features direct glycosidic coupling between the aglycone and a trichloroacetimidate glucuronyl donor. Structural elucidation of a unique and unexpected difluoroboron complex of the desired glycosidic coupling product along with optimization of the synthetic steps is described.
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854267
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