Author/Authors :
Oliveira، نويسنده , , Alfredo R.M. and Villar، نويسنده , , José A.F.P. and Simonelli، نويسنده , , Fabio and Gariani، نويسنده , , Rogério A. and Wosch، نويسنده , , Celso L. and Zarbin، نويسنده , , Paulo H.G.، نويسنده ,
Abstract :
In this letter we present a new 2,4,4-trimethyl-2-oxazoline anion-zinc derivative that has a remarkable thermal stability when compared with the corresponding cyanocuprate counterpart. The yields from conjugated addition to several 2-nitrovinyl benzenes are moderate to good and the reaction itself is easier to execute and cleaner. As an application, this methodology was applied to an alternative synthesis of (±)-Rolipram, a drug with several interesting biological activities.
