Title of article
Towards the total chemical synthesis of integral membrane proteins: a general method for the synthesis of hydrophobic peptide-αthioester building blocks
Author/Authors
Johnson، نويسنده , , Erik C.B. and Kent، نويسنده , , Stephen B.H. Kent، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
5
From page
1795
To page
1799
Abstract
Modification of a peptide-αthioester with a sequence of six arginines on the thioester leaving group can render soluble all peptides derived from a polytopic integral membrane protein. This strategy greatly simplifies the synthesis of peptide-αthioester building blocks for the total chemical synthesis of integral membrane proteins by native chemical ligation.
Keywords
chemical protein synthesis , Integral membrane proteins , thioester , native chemical ligation , diacylglycerol kinase
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854411
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