Total synthesis of (±)-debromoflustramine B and E and (±)-debromoflustramide B based on one-pot intramolecular Ullmann coupling and Claisen rearrangement

Total syntheses of (±)-debromoflustramine B and E and (±)-debromoflustramide B were accomplished using a common and versatile intermediate spirocyclic oxindole 14, which was concisely prepared through intramolecular Ullmann coupling and Claisen rearrangement from iodoindole 13 on a multigram scale.