Author/Authors :
Salim، نويسنده , , Angela A. and Su، نويسنده , , Bao-Ning and Chai، نويسنده , , Hee-Byung and Riswan، نويسنده , , Soedarsono and Kardono، نويسنده , , Leonardus B.S. and Ruskandi، نويسنده , , Agus and Farnsworth، نويسنده , , Norman R. and Swanson، نويسنده , , Steven M. and Douglas Kinghorn، نويسنده , , A.، نويسنده ,
Abstract :
Four new compounds having an unusual 1,7-dioxadispiro[5.1.5.2]-12-ene-11-one tricyclic ring system (1–4), their potential precursor, 5R-hydroxy-1-(4-hydroxyphenyl)-eicosan-3-one (5), and two known compounds, aculeatins A (6) and B (7), have been isolated from Amomum aculeatum. All compounds were characterized by spectroscopic methods and the configurations were established by 2D NOE correlations. Compounds 1–4, 6, and 7 showed cytotoxic activity against several human cancer cell lines.
Keywords :
5R-Hydroxy-1-(4-hydroxyphenyl)-eicosan-3-one , NMR data , Amomum aculeatum , zingiberaceae , Aculeatols A–D , Dioxadispiroketals
