Title of article
Synthesis and evaluation of hexitol nucleoside congeners as ambiguous nucleosides
Author/Authors
Lambertucci، نويسنده , , Catia and Schepers، نويسنده , , Guy and Cristalli، نويسنده , , Gloria and Herdewijn، نويسنده , , Piet and Aerschot، نويسنده , , Arthur Van، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
3
From page
2143
To page
2145
Abstract
A series of anhydrohexitol nucleoside congeners was synthesized as ambiguous or so-called universal nucleosides and was evaluated for their hybridization potential and discrimination properties. The 1,5-anhydro-2,3-dideoxy-2-(5-nitroindazol-1-yl)-d-arabino-hexitol 4e showed the lower spread in Tm values upon hybridization to the natural bases, with minimal destabilization, and therefore behaved as a true ambiguous nucleoside.
Keywords
Duplex stability , universal nucleosides , Anhydrohexitol nucleosides , Ambiguous base , Degenerate nucleosides
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854536
Link To Document