Author/Authors :
Umkehrer، نويسنده , , Michael and Ross، نويسنده , , Günther and Jنger، نويسنده , , Nadine and Burdack، نويسنده , , Christoph and Kolb، نويسنده , , Jürgen and Hu، نويسنده , , Hong and Alvim-Gaston، نويسنده , , Maria and Hulme، نويسنده , , Christopher، نويسنده ,
Abstract :
A new and versatile synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition is described. The reported novel synthetic approach leads to pharmacologically interesting scaffolds containing three points of potential diversity, which previously were not accessible under conventional conditions. In addition, this novel synthetic procedure is amenable to the assembly of libraries with this interesting core structure.
Keywords :
Three component condensation (3CC) , Combinatorial chemistry , 4-cycloaddition , 2-c]pyrimidines
