Title of article :
Lewis and Brönsted acid catalyzed Friedel–Crafts hydroxyalkylation of mucohalic acids: a facile synthesis of functionalized γ-aryl γ-butenolides
Author/Authors :
Zhang، نويسنده , , Ji and Blazecka، نويسنده , , Peter G. and Curran، نويسنده , , Timothy T.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
A catalytic, green and practical method for Friedel–Crafts hydroxyalkylation of mucohalic acid has been accomplished. Reaction of mucohalic acids with various electron-rich aromatic compounds in the presence of catalytic (1 mol % to 10 mol %) In(OTf)3 or Brönsted acid, such as H2SO4 in acetic acid provides γ-aryl γ-butenolides in moderate to excellent yield.
Keywords :
Friedel–Crafts hydroxyalkylation , Mucochloric acid , Mucobromic acid , Indium(III) salt , green chemistry
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
