Author/Authors :
Prasad، نويسنده , , C.V.C. and Mercer، نويسنده , , Stephen E. and Dubowchik، نويسنده , , Gene M. and Macor، نويسنده , , John E.، نويسنده ,
Abstract :
Enantioselective synthesis of constrained trans-aminobenzazepinone utilizing palladium-mediated Jeffery–Heck reaction and rhodium(II) catalyzed asymmetric hydrogenation as key steps are described. Diverse functional groups such as alkyl, aryl, basic or amino acid moieties were introduced with minimal racemization.
