Author/Authors :
Schwarz، نويسنده , , Nicolle and Tillack، نويسنده , , Annegret and Alex، نويسنده , , Karolin and Sayyed، نويسنده , , Iliyas Ali and Jackstell، نويسنده , , Ralf and Beller، نويسنده , , Matthias، نويسنده ,
Abstract :
The palladium-catalyzed amination of a 3-silyloxy-substituted bromo-indole with primary and secondary amines is described for the first time. In the presence of the novel catalyst system of Pd(OAc)2/N-phenyl-2-(di-1-adamantylphosphino)pyrrole potentially bioactive amino-functionalized indole derivatives are obtained in a general manner in high yield.
Keywords :
amination , C–N coupling , PALLADIUM , indoles
