Title of article
A convenient microwave-assisted synthesis of N-glycosyl amino acids
Author/Authors
Paolini، نويسنده , , Ilaria and Nuti، نويسنده , , Francesca and de la Cruz Pozo-Carrero، نويسنده , , Maria and Barbetti، نويسنده , , Francesca and Kolesinska، نويسنده , , Beata and Kaminski، نويسنده , , Zbigniew J. and Chelli، نويسنده , , Mario and Papini، نويسنده , , Anna M.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
2901
To page
2904
Abstract
Optimization of coupling reactions of glycosylamines with Fmoc-protected aspartic acid, by microwave approach, is described. Different reaction conditions, quantities of substrates and solvents were tested to develop simple and reproducible methodologies. The best results were obtained using new triazine-based coupling reagents with a monomode microwave Discover® BenchMate™ instrument (CEM). The N-glycosyl amino acids were then deprotected to achieve final products for SPPS.
Keywords
Synthetic glycopeptide probe , Coupling reagent , Solid-phase peptide synthesis , Microwave-assisted synthesis , N-Glycosyl amino acids
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854778
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