Author/Authors :
Achard، نويسنده , , Thierry J.R. and Belokon’، نويسنده , , Yuri N. and Ilyin، نويسنده , , Michael and Moskalenko، نويسنده , , Margarita and North، نويسنده , , Michael and Pizzato، نويسنده , , Francesca، نويسنده ,
Abstract :
A cobalt(salen) complex has been shown to catalyse the asymmetric Darzens condensation between α-haloamides and aldehydes, allowing both the relative and absolute stereochemistry of the epoxy-amide products to be controlled. Under optimal conditions, cis-epoxides can be obtained diastereoselectively with up to 50% enantiomeric excess, whilst by changing the leaving group and base, trans-epoxides can be produced diastereoselectively with up to 43% enantiomeric excess.
