Title of article
Enantio- and diastereoselective Darzens condensations
Author/Authors
Achard، نويسنده , , Thierry J.R. and Belokon’، نويسنده , , Yuri N. and Ilyin، نويسنده , , Michael and Moskalenko، نويسنده , , Margarita and North، نويسنده , , Michael and Pizzato، نويسنده , , Francesca، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
5
From page
2965
To page
2969
Abstract
A cobalt(salen) complex has been shown to catalyse the asymmetric Darzens condensation between α-haloamides and aldehydes, allowing both the relative and absolute stereochemistry of the epoxy-amide products to be controlled. Under optimal conditions, cis-epoxides can be obtained diastereoselectively with up to 50% enantiomeric excess, whilst by changing the leaving group and base, trans-epoxides can be produced diastereoselectively with up to 43% enantiomeric excess.
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854797
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