Title of article :
An efficient one-pot, two-step synthesis of 4-substituted 1-heteroarylpiperazines under microwave irradiation conditions
Author/Authors :
Wang، نويسنده , , Hong-Jun and Earley، نويسنده , , William G. and Lewis، نويسنده , , Robert M. and Srivastava، نويسنده , , Rajiv R. and Zych، نويسنده , , Andrew J. and Jenkins، نويسنده , , David M. and Fairfax، نويسنده , , David J.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
A highly efficient one-pot, two-step microwave procedure has been developed for the synthesis of 4-substituted 1-heteroarylpiperazines. Microwave heating of heteroaryl chlorides with 1,4-diazabicyclo[2.2.2]octane (DABCO) at 160 °C for 15 min yielded 1-heteroaryl-4-(2-chloroethyl)piperazines, which could be further reacted with various nucleophiles, again under microwave irradiation conditions, to give an array of 4-substituted 1-heteroarylpiperazines in good to excellent yields.
Keywords :
Dealkylation , Heteroaryl , Piperazine , microwave irradiation , Dabco
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
