Title of article
An efficient one-pot, two-step synthesis of 4-substituted 1-heteroarylpiperazines under microwave irradiation conditions
Author/Authors
Wang، نويسنده , , Hong-Jun and Earley، نويسنده , , William G. and Lewis، نويسنده , , Robert M. and Srivastava، نويسنده , , Rajiv R. and Zych، نويسنده , , Andrew J. and Jenkins، نويسنده , , David M. and Fairfax، نويسنده , , David J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
3043
To page
3046
Abstract
A highly efficient one-pot, two-step microwave procedure has been developed for the synthesis of 4-substituted 1-heteroarylpiperazines. Microwave heating of heteroaryl chlorides with 1,4-diazabicyclo[2.2.2]octane (DABCO) at 160 °C for 15 min yielded 1-heteroaryl-4-(2-chloroethyl)piperazines, which could be further reacted with various nucleophiles, again under microwave irradiation conditions, to give an array of 4-substituted 1-heteroarylpiperazines in good to excellent yields.
Keywords
Dealkylation , Heteroaryl , Piperazine , microwave irradiation , Dabco
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854822
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