Author/Authors :
Choudhury، نويسنده , , Anusuya and Breslav، نويسنده , , Michael and Grimm، نويسنده , , Jeffrey S. and Xiao، نويسنده , , Tong and Xu، نويسنده , , Dawei and Sorgi، نويسنده , , Kirk L.، نويسنده ,
Abstract :
A one-pot sequential process consisting of nucleophilic substitution of the lithiated acetylides with Weinreb amides followed by a Michael reaction of the extruded N-methoxy-N-methylamine after quenching with saturated NH4Cl, provided β-enamino ketones in high yield and in a single geometrical isomeric form. It has been demonstrated that this method is applicable to a wide variety of such amides and to different acetylides.
