Author/Authors :
Chen، نويسنده , , Li-Jun and Xu، نويسنده , , Qi-Hai and Huang، نويسنده , , Hao and Lin، نويسنده , , Jing-Rong and Tian، نويسنده , , Wei-Sheng، نويسنده ,
Abstract :
5(6)-Dihydro-OSW-1 (1), an analogue of OSW-1 with the potent anticancer activity, was synthesized by utilizing the intact skeleton of tigogenin in 13 steps in 9.0% overall yield. This synthesis demonstrated an effective and reasonable synthetic strategy for bioactive steroids with side chains as compared with their routine synthesis.
