Organic synthesis in water: 1,3-dipolar cycloaddition reactions at ambient temperature with aqueous suspensions of solid reactants

Huisgen cycloaddition reactions of the insoluble yellow solid, phthalazinium dicyanomethanide occurred readily for vigorously stirred aqueous suspensions when the solid dipolarophile had solubility >ca. 10−3 mol L−1. For a solubility of ca. 10−4 mol L−1, liquefaction of the dipolarophile was necessary in order to achieve reactions.