Author/Authors :
Horvلth، نويسنده , , Andrلs and Ruttens، نويسنده , , Bart and Herdewijn، نويسنده , , Piet، نويسنده ,
Abstract :
A stereoselective synthesis leading to (−)-ara-cyclohexenyl-adenine is described. The synthesis starts from methyl-α-d-glucopyranose and involves an isomerization step, selective protection/deprotection chemistry, a Ferrier rearrangement and a Mitsunobu reaction. This is the first total synthesis of an enantiomeric pure ara-type cyclohexenyl nucleoside.
