Iterative two-step strategy for C2–C4′ linked poly-oxazole synthesis using Suzuki–Miyaura cross-coupling reaction

An iterative method for the synthesis of C2–C4′ linked poly-oxazoles has been developed. This efficient two-step repetitive process includes TBS–iodine exchange reaction and Suzuki–Miyaura cross-coupling reaction with oxazolylboronate 8, which allows appending a bis-oxazole moiety per each iteration. The synthesis of bis-, tris-, tetrakis-, pentakis-, and hexakis-oxazoles (10, 14, 22, 18, and 24) was achieved starting from the common intermediate 7 in 1–5 steps.