Title of article :
Clinical experience with α-galactosylceramide (KRN7000) in patients with advanced cancer and chronic hepatitis B/C infection
Author/Authors :
Schneiders، نويسنده , , Famke L. and Scheper، نويسنده , , Rik J. and von Blomberg، نويسنده , , B. Mary E. and Woltman، نويسنده , , Andrea M. and Janssen، نويسنده , , Harry L.A. and van den Eertwegh، نويسنده , , Alfons J.M. and Verheul، نويسنده , , Henk M.W. and de Gruijl، نويسنده , , Tanja D. and van der Vliet، نويسنده , , Hans J.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2011
Pages :
12
From page :
130
To page :
141
Abstract :
For over a century, research has sought ways to boost the immune system in order to eradicate tumors and viruses that exist after escaping immunosurveillance. For the treatment of cancer and hepatitis immunotherapeutic strategies have overall had limited clinical success. An urgent need exists therefore to introduce more effective therapeutic approaches. Invariant (i)NKT cells constitute a conserved T lymphocyte lineage with dominant immunoregulatory, antitumor and antiviral effector cell properties. iNKT specifically recognize the glycolipid α-galactosylceramide in the context of CD1d resulting in their activation. Activated iNKT can promote the development of a long-lasting Th1 biased proinflammatory immune response as demonstrated in multiple tumor-metastasis and viral infection models. Here, we will provide a brief overview of the preclinical data of α-galactosylceramide that formed the basis for subsequent clinical trials in patients with advanced cancer and chronic hepatitis B/C, and elaborate on our own clinical experience with α-galactosylceramide in these patient groups.
Keywords :
?-galactosylceramide , KRN7000 , CANCER , Chronic hepatitis B/C infection , iNKT cells
Journal title :
Clinical Immunology
Serial Year :
2011
Journal title :
Clinical Immunology
Record number :
1855164
Link To Document :
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