Author/Authors :
Rutkowska، نويسنده , , Magdalena and Lenart، نويسنده , , Marzena and Bukowska-Strakovà، نويسنده , , Karolina and Szaflarska، نويسنده , , Anna and Pituch-Noworolska، نويسنده , , Anna and Kobylarz، نويسنده , , Krzysztof and B?aut-Szl?sarczyk، نويسنده , , Anita and Zwonarz، نويسنده , , Katarzyna and Zembala، نويسنده , , Marek and Siedlar، نويسنده , , Maciej، نويسنده ,
Abstract :
B cell dysfunction represents a central feature in HIV infection and pathogenesis. Our recent studies have shown that peripheral and lymphoid double positive CD21+CD27+ B cells were able to become activated and proliferate at higher rates than other B cell subpopulations. Increased proliferation of tonsillar memory B cells was identified compared to other tissues examined. Here, we demonstrate the decreased proliferation of tonsillar memory (CD21+CD27+) B cells during acute SIV infection also suggests that these cells may play an important role in SIV pathogenesis. Our findings demonstrate that SIV infection may induce selective defective responses in specific tissues, by suppressing memory B cell proliferation in tissues.
