Author/Authors :
Buron، نويسنده , , Frédéric and Turck، نويسنده , , Alain and Plé، نويسنده , , Nelly and Bischoff، نويسنده , , Laurent and Marsais، نويسنده , , Francis، نويسنده ,
Abstract :
We report herein a concise and biomimetic synthesis of a precursor of barrenazine A, a cytotoxic alkaloid. The C2-symmetry of this molecule suggested the dimerization of an aminoketone, as the precursor of the central core pyrazine. This compound was prepared by assembly of aspartic acid and glycine.
Keywords :
marine alkaloid , Barrenazine , Amino acid , Pyrazine synthesis
