Author/Authors :
Broady، نويسنده , , Simon D. and Golden، نويسنده , , Michael D. and Leonard، نويسنده , , John and Muir، نويسنده , , James C. and Maudet، نويسنده , , Mickael، نويسنده ,
Abstract :
A modified Ziegler Ullmann coupling process has been developed as the key step in an effective synthesis of (S)-(−)-N-acetylcolchinol, analogues of which are selective vascular targeting agents with potential importance in cancer chemotherapy. Asymmetric induction is achieved by enamide hydrogenation using FerroTANE catalysts.
