Title of article :
A palladium- and copper-free cross-coupling of ethyl 3-halo-2-propynoates with 4,5,6,7-tetrahydroindoles on alumina
Author/Authors :
Trofimov، نويسنده , , B.A. and Sobenina، نويسنده , , L.N. and Demenev، نويسنده , , A.P. and Stepanova، نويسنده , , Z.V. and Petrova، نويسنده , , O.V. and Ushakov، نويسنده , , I.A. and Mikhaleva، نويسنده , , A.I.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
Ethyl 3-halo-2-propynoates undergo facile (no heating, no base, no solvent) palladium- and copper-free cross-coupling with 4,5,6,7-tetrahydroindoles on alumina to afford the corresponding 4,5,6,7-tetrahydroindole-2-propynoates in 46% and 71% yields. The yield of the by-products [ethyl 3,3-di(4,5,6,7-tetrahydro-1H-indol-2-yl)acrylates] under appropriate conditions can reach 79%.
Keywords :
7-Tetrahydroindoles , 5 , pyrroles , Ethyl 3-halo-2-propynoates , alumina , cross-coupling , 4 , 5 , Ethyl 3 , 3-di(4 , 5 , 6 , 4 , 7-tetrahydro-1H-indol-2-yl)acrylates , 6 , 7-Tetrahydroindole-2-propynoates , 6
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
