Title of article :
The fragmentation reaction of 16R-bromopregnane-3S,20S-diol
Author/Authors :
Lin، نويسنده , , Jing-Rong and Zhou، نويسنده , , Nan-Yan and Xu، نويسنده , , Qi-Hai and Jian، نويسنده , , Shi-Feng and Tian، نويسنده , , Wei-Sheng، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
16R-Bromopregnane-3S,20S-diol reacted with potassium t-butoxide to afford androst-16-en-3S-ol in a moderate yield via fragmentation reaction. The latter is a key intermediate for the synthesis of 5α-androst-16-en-3-one, as boar sex pheromone, and other steroidal drugs. In addition, 16R,20S-epoxypregnane-3S-ol was also obtained as a major product by changing the reaction solvent.
Keywords :
Tigogenin , Pregnanetriol , 16R-Bromopregnane-3S , 20S-diol , fragmentation
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
