Title of article :
The synthesis of facial amphiphile 3α,7α-diaminocholestane
Author/Authors :
Khan، نويسنده , , Sharaf Nawaz and Cho، نويسنده , , Nam-Ju and Kim، نويسنده , , Hong-Seok، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
The facial amphiphile 3α,7α-diaminocholestane 3 was synthesized from 3β-acetoxy-7-ketocholestane 1 through a stepwise reductive amination. The reductive amination of 1 with NH4OAc in the presence of NaBH3CN, and protection with Boc2O yielded 7α-(tert-butyloxycarbonyl)-aminocholestane 4 in 86% yield. The reductive amination of 6, which was obtained from 4 after hydrolysis and subsequent oxidation, with NH4OTf in the presence of NaBH(OEh)3 provided 3 in 75% yield after protection with Boc2O.
Keywords :
Facial amphiphile , reductive amination , 7?-Diaminocholestane , 3? , stereoselective
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
