Title of article :
Decreased interferon-α production in response to CpG DNA dysregulates cytokine responses in patients with multiple sclerosis
Author/Authors :
Hirotani، نويسنده , , Makoto and Niino، نويسنده , , Masaaki and Fukazawa، نويسنده , , Toshiyuki and Yaguchi، نويسنده , , Hiroaki and Nakamura، نويسنده , , Masakazu and Kikuchi، نويسنده , , Seiji and Sasaki، نويسنده , , Hidenao، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2012
Pages :
7
From page :
145
To page :
151
Abstract :
Type I interferons (IFNs), represented by IFN-α and β, activate immune effector cells belonging to the innate and adaptive immune systems. Plasmacytoid dendritic cells (pDCs) produce IFN-α in response to CpG DNA. We aimed to examine the impact of pDC-produced IFN-α on the adaptive immune system in Multiple Sclerosis (MS). Our results demonstrated that CpG DNA-induced IFN-α production was significantly decreased in PBMCs from MS patients. Decreased levels of IL-12 p70, IFN-γ, and IL-17 and increased level of IL-10 were found in CpG DNA-treated PBMCs of healthy subjects unlike in those from MS patients. In samples pre-treated with IFN-α and IFN-β, decreased levels of IL-12 p70, IFN-γ, and IL-17 and increased level of IL-10 were detected in PBMCs from MS patients. These results suggest that CpG DNA-induced decreased IFN-α production causes pro-inflammatory cytokine secretion, and either IFN-α or IFN-β induces anti-inflammatory cytokine secretion in the adaptive immune system in MS.
Keywords :
MS , Type I IFN , IFN-? , TLR9 , innate immunity , PDC
Journal title :
Clinical Immunology
Serial Year :
2012
Journal title :
Clinical Immunology
Record number :
1855688
Link To Document :
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