Author/Authors :
Savkovic، نويسنده , , Borislav and Macpherson، نويسنده , , Janet L. and Zaunders، نويسنده , ,
John K. Kelleher، نويسنده , , Anthony D. and Knop، نويسنده , , Alison E. and Pond، نويسنده , , Susan C. Evans، نويسنده , , Louise and Symonds، نويسنده , , Geoff and Murray، نويسنده , , John M.، نويسنده ,
Abstract :
Analysis and mathematical modeling of T-lymphocyte perturbation following administration of granulocyte colony stimulating factor (G-CSF) and two large-scale aphereses are reported. 74 HIV-1 positive antiretroviral-treated individuals were infused with gene- or sham-transduced CD34+ hematopoietic stem cells (HSC) in a Phase II clinical trial. T cell numbers were examined in four phases: 1) during steady state; 2) increases in peripheral blood (PB) following G-CSF administration; 3) depletion post-aphereses and 4) reconstitution post HSC infusion. The present analysis provides the first direct estimate of CD4+ T cell distribution and trafficking in HIV-infected individuals on stable HAART, indicating that CD4+ T lymphocytes in PB represent 5.5% of the pool of CD4+ T lymphocytes that traffic to PB.
Keywords :
Compartment model , apheresis , Granulocyte-colony stimulating factor , stem cell transplantation , HIV , Lymphocyte distribution and trafficking
