Title of article
High-yielding metalloenzymatic dynamic kinetic resolution of fluorinated aryl alcohols
Author/Authors
Bogلr، نويسنده , , Krisztiلn and Bنckvall، نويسنده , , Jan-E.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
5471
To page
5474
Abstract
Dynamic kinetic resolution (DKR) of various fluorinated aryl alcohols by a combination of lipase-catalyzed enzymatic resolution with in situ ruthenium-catalyzed alcohol racemization is described. (R)-Selective Candida antarctica lipase B (CALB) was employed for transesterification of different fluoroaryl alcohols in DKR reactions delivering the corresponding acetates in high yield (⩾97%) with excellent enantiomeric excess (⩾98%).
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1855841
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