Author/Authors :
Przewloka، نويسنده , , Teresa and Chen، نويسنده , , Shoujun and Xia، نويسنده , , Zhiqiang and Li، نويسنده , , Hao and Zhang، نويسنده , , Shijie and Chimmanamada، نويسنده , , Dinesh and Kostik، نويسنده , , Elena and James، نويسنده , , David and Koya، نويسنده , , Keizo and Sun، نويسنده , , Lijun، نويسنده ,
Abstract :
A number of 3-acylated indolizines were synthesized in good to excellent yields by a newly established reaction between picolinium salts and the methylsulfate salt of A (R = Me), the adduct formed from DMF–Me2SO4 as the key reagent. The low cost, short reaction time, mild reaction condition, and easy purification of the products make this an attractive new method for the synthesis of indolizine compounds. A variety of functional groups (nitro, cyano, ester, methoxy, and halogens) were well tolerated under the reaction conditions.
Keywords :
Indolizine , Regioselective synthesis , Methyl sulfate , DMF , Picolinium salt
