Title of article
Synthetic approach to condensed heterocyclic analogues from etoposide revisited. Synthesis of A-ring pyridazine etoposide
Author/Authors
Bertounesque، نويسنده , , Emmanuel and Meresse، نويسنده , , Philippe and Monneret، نويسنده , , Claude and Florent، نويسنده , , Jean-Claude، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
5781
To page
5784
Abstract
The synthetic approach to condensed heterocyclic analogues from etoposide was revisited. The described procedure allows the synthesis of A-ring pyridazine etoposide 13, featuring the use of tetrakis(triphenylphosphine)palladium as catalyst under optimized conditions in the key Stille cross coupling between bistriflate 14 and the vinylstannane without epimerization at C-2. The TBDMS-protecting group was critical to cleanly obtain the pivotal intermediate 19.
Keywords
Etoposide , Stille reaction , Topoisomerase II , anticancer drugs
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1856006
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