Title of article :
Direct synthesis of protected diethyl 1,2-diaminoalkylphosphonates
Author/Authors :
B?aszczyk، نويسنده , , Roman and Gajda، نويسنده , , Tadeusz، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
An efficient, diastereoselective synthesis of 5-substituted (2-thioxo-imidazolidin-4-yl)phosphonic acid diethyl esters from metallated diethyl isothiocyanatomethylphosphonate and activated imines has been developed. The three-step transformation of imidazolidine-2-thione derivatives into 1,2-diaminoalkylphosphonic acids is also described.
Keywords :
Imidazolidine-2-thiones , imines , 1 , 2-diaminoalkylphosphonic acids , Isothiocyanates , nucleophilic addition , Diethyl isothiocyanatomethylphosphonate
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
