Author/Authors :
Ibrahem، نويسنده , , Ismail and Rios، نويسنده , , Ramon and Vesely، نويسنده , , Jan and Cَrdova، نويسنده , , Armando، نويسنده ,
Abstract :
The highly chemo- and enantioselective organocatalytic [C+NC+CC] coupling process between aldehydes, dialkyl 2-aminomalonates and α,β-unsaturated aldehydes is presented. The reaction gives access to highly functionalized pyrrolidine derivatives in good yields with >10:1 dr and 90–98% ee.
