Author/Authors :
Arasappan، نويسنده , , Ashok and Venkatraman، نويسنده , , Srikanth and Padilla، نويسنده , , Angela I. and Wu، نويسنده , , Wanli and Meng، نويسنده , , Tao and Jin، نويسنده , , Yan Loi Wong ، نويسنده , , Jesse and Prongay، نويسنده , , Andrew and Girijavallabhan، نويسنده , , Viyyoor and George Njoroge، نويسنده , , F.، نويسنده ,
Abstract :
A practical and efficient route toward synthesis of amino acid derivatives containing β-quaternary center has been developed using diastereoselective Strecker reaction. The method was employed for preparation of >100 g of β-methylcyclohexyl glycine derivative, 21. Incorporation of some of the hindered amino acid derivatives at the P3 position resulted in potent HCV NS3 serine protease inhibitors.
