Title of article
Practical and efficient method for amino acid derivatives containing β-quaternary center: application toward synthesis of hepatitis C virus NS3 serine protease inhibitors
Author/Authors
Arasappan، نويسنده , , Ashok and Venkatraman، نويسنده , , Srikanth and Padilla، نويسنده , , Angela I. and Wu، نويسنده , , Wanli and Meng، نويسنده , , Tao and Jin، نويسنده , , Yan Loi Wong ، نويسنده , , Jesse and Prongay، نويسنده , , Andrew and Girijavallabhan، نويسنده , , Viyyoor and George Njoroge، نويسنده , , F.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
5
From page
6343
To page
6347
Abstract
A practical and efficient route toward synthesis of amino acid derivatives containing β-quaternary center has been developed using diastereoselective Strecker reaction. The method was employed for preparation of >100 g of β-methylcyclohexyl glycine derivative, 21. Incorporation of some of the hindered amino acid derivatives at the P3 position resulted in potent HCV NS3 serine protease inhibitors.
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1856325
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