Title of article :
Synthetic studies on neomarinone: practical and efficient stereoselective synthesis of the side chain
Author/Authors :
Suلrez، نويسنده , , Rosa M. and Montserrat Martيnez، نويسنده , , M. and Sarandeses، نويسنده , , Luis A. and Pérez Sestelo، نويسنده , , José، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
A practical and efficient stereoselective synthesis of the side chain of neomarinone is reported. The synthesis was achieved in six steps (41% overall yield) from 2-methyl-2-cyclohexenone. The key step is a novel stereoselective 1,4-conjugate addition/enolate alkylation by an epoxide-opening reaction.
Keywords :
natural product synthesis , 1 , 4-Addition reactions , Enolate alkylation reactions , stereoselective synthesis
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
