Author/Authors :
Kinzel، نويسنده , , Olaf D. and Monteagudo، نويسنده , , Edith and Muraglia، نويسنده , , Ester and Orvieto، نويسنده , , Federica and Pescatore، نويسنده , , Giovanna and Ferreira، نويسنده , , Maria del Rosario Rico and Rowley، نويسنده , , Michael and Summa، نويسنده , , Vincenzo، نويسنده ,
Abstract :
An efficient synthesis of methyl 9-amino-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxylate as a late stage intermediate for a new class of HIV-1 integrase inhibitors is described. After construction of the bicyclic core scaffold, a stereoselective introduction of the chiral amino group in the 9-position is achieved.
Keywords :
Tetrahydropyridopyrimidone , Integrase inhibitor , 1 , 2 , 4-Oxadiazoline , Amidoxime
