Author/Authors :
Li، نويسنده , , Nian-Guang and Wang، نويسنده , , Jin-Xin and Liu، نويسنده , , Xiao-Rong and Lin، نويسنده , , Chang-Jun and You، نويسنده , , Qidong and Guo، نويسنده , , Qing-Long، نويسنده ,
Abstract :
A short and efficient route to the synthesis of 4-oxa-tricyclo[4.3.1.0]decan-2-one scaffold 12 in good yield is reported. Essential to the synthesis was the implementation of selective protection of the catechol system in xanthone 2 with Ph2CCl2 and MOM groups. Subsequently, a biomimetic tandem Claisen/Diels–Alder reaction occurred to produce the desired tricyclic scaffold 11a as a single isomer. A rationalization of the excellent region and stereoselectivity of this transformation was also proposed.
