Title of article
Catalytic enantioselective Friedel–Crafts alkylation at the 2-position of indole with simple enones
Author/Authors
Blay، نويسنده , , Gonzalo and Fernلndez، نويسنده , , Isabel and Pedro، نويسنده , , José R. and Vila، نويسنده , , Carlos، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
6731
To page
6734
Abstract
A procedure for the enantioselective alkylation of indole at the 2-position with simple non-chelating enones is described for the first time. Reaction between 4,7-dihydroindole and enones in the presence of zirconium(IV)–BINOL complexes, followed by a p-benzoquinone oxidation gives indoles alkylated at the 2-position with good yields and moderate enantioselectivities.
Keywords
Heterocycles , conjugate addition , Enantioselective catalysis , Binol , Zirconium complexes , Dihydroindole
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1856541
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