Author/Authors :
Luu، نويسنده , , Van Phi and Hevezi، نويسنده , , Peter and Vences-Catalan، نويسنده , , Felipe and Maravillas-Montero، نويسنده , , José Luis and White، نويسنده , , Clayton Alexander and Casali، نويسنده , , Paolo and Llorente، نويسنده , , Luis and Jakez-Ocampo، نويسنده , , Juan and Lima، نويسنده , , Guadalupe and Vilches-Cisneros، نويسنده , , Natalia and Flores-Gutiérrez، نويسنده , , Ju، نويسنده ,
Abstract :
We have identified Tspan33 as a gene encoding a transmembrane protein exhibiting a restricted expression pattern including expression in activated B cells. TSPAN33 is a member of the tetraspanin family. TSPAN33 is not expressed in resting B cells, but is strongly induced in primary human B cells following activation. Human 2E2 cells, a Burkittʹs lymphoma-derived B cell model of activation and differentiation, also upregulate TSPAN33 upon activation. TSPAN33 is expressed in several lymphomas including Hodgkinʹs and Diffuse large B cell lymphoma. TSPAN33 is also expressed in some autoimmune diseases where B cells participate in the pathology, including rheumatoid arthritis patients, systemic lupus erythematosus (SLE), and in spleen B cells from MRL/Faslpr/lpr mice (a mouse model of SLE). We conclude that TSPAN33 may be used as a diagnostic biomarker or as a target for therapeutic antibodies for treatment of certain B cell lymphomas or autoimmune diseases.
Keywords :
Tetraspanin 33 , B cells , Lymphoma , lupus erythematosus , rheumatoid arthritis , Biomarker
