Title of article :
A simple one-pot procedure for the direct conversion of alcohols into alkyl nitriles using TsIm
Author/Authors :
Soltani Rad، نويسنده , , Mohammad Navid and Khalafi-Nezhad، نويسنده , , Ali and Behrouz، نويسنده , , Somayeh and Faghihi، نويسنده , , Mohammad Ali، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
A convenient and efficient one-pot preparation of nitriles from alcohols using N-(p-toluenesulfonyl)imidazole (TsIm) is described. In this method, treatment of alcohols with a mixture of NaCN, TsIm and triethylamine in the presence of catalytic amounts of tetra-n-butylammonium iodide (TBAI) in refluxing DMF furnishes the corresponding alkyl nitriles in good yields. This methodology is highly efficient for various structurally diverse alcohols with selectivity for ROH: 1° > 2° > 3°.
Keywords :
N-(p-Toluenesulfonyl)imidazole (TsIm) , alcohol , Triethylamine (TEA) , Tetrabutylammonium iodide (TBAI) , Nitrile
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
