Title of article
A simple one-pot procedure for the direct conversion of alcohols into alkyl nitriles using TsIm
Author/Authors
Soltani Rad، نويسنده , , Mohammad Navid and Khalafi-Nezhad، نويسنده , , Ali and Behrouz، نويسنده , , Somayeh and Faghihi، نويسنده , , Mohammad Ali، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
6
From page
6779
To page
6784
Abstract
A convenient and efficient one-pot preparation of nitriles from alcohols using N-(p-toluenesulfonyl)imidazole (TsIm) is described. In this method, treatment of alcohols with a mixture of NaCN, TsIm and triethylamine in the presence of catalytic amounts of tetra-n-butylammonium iodide (TBAI) in refluxing DMF furnishes the corresponding alkyl nitriles in good yields. This methodology is highly efficient for various structurally diverse alcohols with selectivity for ROH: 1° > 2° > 3°.
Keywords
N-(p-Toluenesulfonyl)imidazole (TsIm) , alcohol , Triethylamine (TEA) , Tetrabutylammonium iodide (TBAI) , Nitrile
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1856567
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