Author/Authors :
Stevens، نويسنده , , Christian V. and Van Meenen، نويسنده , , Ellen and Masschelein، نويسنده , , Kurt G.R. and Eeckhout، نويسنده , , Yves and Hooghe، نويسنده , , Wim and D’hondt، نويسنده , , Bart and Nemykin، نويسنده , , Victor N. and Zhdankin، نويسنده , , Viktor V.، نويسنده ,
Abstract :
In this Letter the synthesis of benzospiro-indolizidinepyrrolidinones is described by a domino atom transfer radical cyclization reaction using a copper catalyst. The structure of one of the products was established by single crystal X-ray diffraction. The investigated precursors, bearing a homo allyl substituent on the N-indole, result in a 5-exo-trig, followed by a 6-endo-trig cyclization. When the N-indole is substituted with an allyl group, only the spiro-cyclization occurs.
Keywords :
Cu(I)Cl , ATRC , Domino reaction , Atom transfer radical cyclization
