Author/Authors :
Hosokawa، نويسنده , , Seijiro and Fumiyama، نويسنده , , Hitoshi and Fukuda، نويسنده , , Hisato and Fukuda، نويسنده , , Tomohiro and Seki، نويسنده , , Masashi and Tatsuta، نويسنده , , Kuniaki، نويسنده ,
Abstract :
The first total synthesis and structural determination of TMC-66, an ECE inhibitor, was achieved in short steps by efficient construction and coupling of segments. The oxidative coupling with phenols attaching to electron-withdrawing groups was realized with a novel copper(II) reagent.
Keywords :
Structural determination , oxidative coupling , total synthesis , TMC-66 , ECE inhibitor
