Author/Authors :
Fan، نويسنده , , Renhua and Wen، نويسنده , , Fengqi and Qin، نويسنده , , Luoheng and Pu، نويسنده , , Dongming and Wang، نويسنده , , Bing، نويسنده ,
Abstract :
(Diacetoxyiodo)benzene (PhI(OAc)2) was found to be a powerful reagent to induce the intramolecular oxidative bromocyclization of homoallylic sulfonamides utilizing KBr as the bromine source. The reaction affords 2-substituted-4-bromo-pyrrolidines in moderate to excellent yields under a mild metal-free condition, and offers good manipulability by avoiding the use of highly toxic and caustic bromine (Br2).
