Unusual heterochiral crystallization tendency of 3-arylphthalide compounds in non-racemic solution: reinvestigation on asymmetric Ni-catalyzed tandem reaction of substituted o-halobenzaldehydes

The phenomenon of unusual heterochiral crystallization tendency of several 3-arylphthalide compounds in non-racemic solution was observed. With this finding, a range of highly enantiomerically enriched 3-arylphthalides were easily accessed through heterochiral crystallization. In addition, the previously reported nickel-catalyzed tandem reaction to asymmetric synthesis of chiral phthalides was reinvestigated and partial data were corrected.