Author/Authors :
Shinada، نويسنده , , Tetsuro and Ishida، نويسنده , , Toshikazu and Hayashi، نويسنده , , Ken-ich and Yoshida، نويسنده , , Yasutaka and Shigeri، نويسنده , , Yasushi and Ohfune، نويسنده , , Yasufumi، نويسنده ,
Abstract :
Novel Leu-enkephalin analogs 10a–c in which the Tyr1, Gly2, or Gly3 residue of Leu-enkephalin 9 was replaced with α-amino squaric acid analog Sq-Tyr 8b or Sq-Gly 8a were synthesized starting from 14 or 18. Conformational analysis of 10a–c together with its model compound 26 and their opioid receptor binding activity were evaluated.
Keywords :
Squaric acid , Isostere , Enkephalin , Amino acid , Peptide
