Title of article :
The emerging role of platelets in adaptive immunity
Author/Authors :
Elzey، نويسنده , , Bennett D. and Sprague، نويسنده , , Daniel L. and Ratliff، نويسنده , , Timothy L.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Pages :
9
From page :
1
To page :
9
Abstract :
Platelets’ foremost role in survival is hemostasis. However, a significant quantity of research has demonstrated that platelets are an integral part of inflammation and can also be potent effector cells of the innate immune response. CD154, a molecule of vital importance to adaptive immune responses, is expressed by activated platelets and has been implicated in platelet-mediated modulation of innate immunity and inflammatory disease states. Recent studies in mice extend the role of platelet CD154 to the adaptive immune response demonstrating that platelets can enhance antigen presentation, improve CD8 T cell responses, and play a critical function in normal T-dependent humoral immunity. The latter studies suggest that the current paradigm for the B cell germinal center response should be modified to include a role for platelets.
Keywords :
Platelets , T cells , B cells , inflammation , dendritic cells , CD154
Journal title :
Cellular Immunology
Serial Year :
2005
Journal title :
Cellular Immunology
Record number :
1857114
Link To Document :
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