Author/Authors :
Michel، نويسنده , , Laure and Chesneau، نويسنده , , Melanie and Manceau، نويسنده , , Philippe and Genty، نويسنده , , Athenais and Garcia، نويسنده , , Alexandra and Salou، نويسنده , , Marion and Elong Ngono، نويسنده , , Annie and Pallier، نويسنده , , Annaïck and Jacq-Foucher، نويسنده , , Marylène and Lefrère، نويسنده , , Fabienne and Wiertlewski، نويسنده , , Sandrine and Soulillou، نويسنده , , Jea، نويسنده ,
Abstract :
Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) typically characterized by the recruitment of T cells into the CNS. However, certain subsets of B cells have been shown to negatively regulate autoimmune diseases and some data support a prominent role for B cells in MS physiopathology. For B cells in MS patients we analyzed subset frequency, cytokine secretion ability and suppressive properties. No differences in the frequencies of the B-cell subsets or in their ability to secrete cytokines were observed between MS and healthy volunteers (HV). Prestimulated B cells from MS patients also inhibited CD4+CD25− T cell proliferation with a similar efficiency as B cells from HV. Altogether, our data show that, in our MS patient cohort, regulatory B cells have conserved frequency and function.
