Title of article
Synthesis of new trifluoromethyl peptidomimetics with a triazole moiety
Author/Authors
Bonnamour، نويسنده , , Julien and Legros، نويسنده , , Julien and Crousse، نويسنده , , Benoit and Bonnet-Delpon، نويسنده , , Danièle، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
3
From page
8360
To page
8362
Abstract
gem-Chloroamine CF3CH(Cl)NHAc 1 reacts in a one-pot sequence with NaN3 to afford trifluoromethyl azido compound 2 and further undergoes a Huisgen 1,3-dipolar cycloaddition with alkynes to yield 1,4-disubstitued 1,2,3-triazoles. The reaction is catalyzed by Cu(II) species (Cu(OAc)2, 10 mol %) without any reducing agent, and the corresponding products are afforded in high yields (74–87%). This process offers thus an entry to new trifluoromethyl pseudopeptides.
Keywords
Catalysis , click chemistry , fluorine , heterocycle , Copper
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1857333
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