Title of article :
Human intestinal αβ IEL clones in celiac disease show reduced IL-10 synthesis and enhanced IL-2 production
Author/Authors :
Kolkowski، نويسنده , , Edgardo C. and Fernلndez، نويسنده , , Marco A. and Pujol-Borrell، نويسنده , , Ricardo and Jaraquemada، نويسنده , , Dolores، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
9
From page :
1
To page :
9
Abstract :
Celiac disease is a gluten-induced T-cell mediated autoimmune process that results in the destruction of the intestinal mucosa and is associated with an expansion of CD8+ CD103+ TCRαβ intraepithelial lymphocytes (IELs) in the damaged epithelium. The role of this IEL population in the pathology is unknown. The aim of this work was to compare the cytokine profile and the cytotoxicity pattern from CD8+ IEL clones isolated from celiac (CD) and non-celiac (NCD) biopsies. We report that the number of IL-10 producing CD clones was significantly lower (26%) than that obtained from the NCD sample (62%). Instead, IL-2 was produced by more CD (44%) than NCD clones (26%). Cytotoxicity patterns against intestinal epithelial cell lines suggest different functional subsets of CD8+ IELs. CD clones capable of high cytotoxicity produced IL-2 whereas most cytotoxic NCD IELs produced IL-10. This clonal analysis indicates that an impaired immune regulation in celiac mucosa may be partially attributed to the low generation of regulatory CD8+ IELs that produce IL-10.
Keywords :
IEL (Intraepithelial lymphocytes) , TCR?? , IL-10 , Celiac disease , IL-2 , CBA (Cytometric bead array)
Journal title :
Cellular Immunology
Serial Year :
2006
Journal title :
Cellular Immunology
Record number :
1857352
Link To Document :
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