Author/Authors :
Wu، نويسنده , , Cheng-Zhu and Cai، نويسنده , , Xing Fu and Dat، نويسنده , , Nguyen Tien and Hong، نويسنده , , Seong Su and Han، نويسنده , , Ah-Reum and Seo، نويسنده , , Eun-Kyoung and Hwang، نويسنده , , Bang Yeon and Nan، نويسنده , , Ji-Xing and Lee، نويسنده , , Dongho and Lee، نويسنده , , Jung Joon، نويسنده ,
Abstract :
Two novel dimeric meroterpenoids, bisbakuchiols A and B, along with (S)-bakuchiol were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). Bisbakuchiols A and B contain an unprecedented dimeric meroterpenoid skeleton in which two meroterpenes are linked through a dioxane bridge. All compounds were evaluated for their potential to inhibit hypoxia-inducible factor-1 (HIF-1) activation induced by hypoxia in a HIF-1-mediated reporter gene assay in AGS human gastric cancer cells. (S)-Bakuchiol inhibited hypoxic activation of HIF-1 with an IC50 value of 6.1 μM.
Keywords :
Fabaceae , Meroterpenoid , Hypoxia-inducible factor-1 , Psoralea corylifolia
