The pathogenesis of septic shock

A new age of treating patients with septic shock is rapidly approaching. A multidrug approach will likely be used to interrupt the systemic inflammatory response to infection, with use of new immune and inflammatory modulating therapies. In this article are reviewed the advances made in understanding the cellular events that cause septic shock. Critical care nurses need to update themselves on this new information to provide optimal care that patients with septic shock demand. Symptoms of septic shock, its hemodynamic characteristics, and the actions of principal inflammatory mediators that cause vasodilation and capillary leak are discussed.